Grail Fronts, 90++ CQs, story nodes, all haven't been an issue.
Co-op Raids (i.e. from Tunguska) is something i haven't been able to do, because i take this game casually and was very late to Tunguska, but i do not think the mod will present any problem in raids. The game should register it as a kill, as if it were any other mob.