I had one character during year 2 on modded game version 4.3.0, who missed two TLSQs (Lone Wolf and Meet the Malfoys).
To be certain I created a new character with mods on 4.2.1 and I just triggered Lone Wolf.
So my guess is, that for some reason the modded game version 4.3.0 interferes with some of the TLSQs...